Polycystic Kidney Disease (PKD) in British Shorthair Cats

Polycystic Kidney Disease (PKD) is an autosomal dominant hereditary condition that can affect British Shorthair cats, especially due to past crossbreeding with Persians. It is characterized by the development of cysts in the kidneys, which can lead to chronic renal failure.

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Etiology

Two main hypotheses for PKD’s origin are:

• Transformation of hyperplastic epithelial cells into polyps.
• Tubular dilation or membrane fragility causing cyst formation.

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Clinical Signs

Symptoms often develop between ages 3 to 10:

• Lethargy
• Anorexia
• Vomiting
• Increased thirst and urination
• Weight loss
• Blood in urine

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Diagnosis

PKD can be diagnosed through:

• Clinical signs and lab tests.
• Imaging (ultrasound, CT, X-ray, biopsy).
• Genetic testing (PCR) is essential for breeding control.

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Treatment

There is no cure, but treatment helps manage the disease:

• Control of systemic hypertension.
• Correction of fluid/electrolyte imbalances.
• Proteinuria reduction.

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Final Considerations

Genetic testing and careful breeding selection are vital to prevent the spread of PKD within the British Shorthair breed.

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